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MeltSim 1.0

The DNA Melting Simulator.


Last Week downloads: 0
Total downloads: 130
  • Last Updated: Aug 30, 2011
  • License: GPL Free
  • OS: Windows 98/NT
  • Requirements: No special requirements

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For MeltSim 1.0Publisher's description


MeltSim is a Photo & Image software developed by MeltSim Team. After our trial and test, the software is proved to be official, secure and free. Here is the official description for MeltSim:

MeltSim is a statistical-mechanical program for calculating melting (denaturation) curves (derivative profiles) and maps of DNA, from genes to genomes. The model is the one-dimensional Ising lattice to which loop Entropy has been appended. The original Algorithm is that of Poland & Scheraga and Poland, with the Fixman & Friere approximation of the loop entropy by a sum of exponentials. Parameters in Poland's original algorithm were evaluated by Blake & Delcourt and provide near-quantitative agreement between observed and calculated Tm, amplitudes, breadths, and areas of transitions obtained under equilibrium conditions.


*The input (sequence) file requires no special format. Bases can be in uppercase and/or lowercase, and no line breaks are required. However, only the letters A, C, G, and T are counted as bases.
*With the helper application called COMPILE, specific sequence Locations in GenBank-formatted files can be converted and read by MeltSim 1.0 for Windows.
*A title will be automatically added to the top of the graph if the first line of the input file contains text beginning with the pound sign (#).
*Bases are normally read in blocks of 100,000 bp and the d(theta)/dT (the first derivative of the portion unmelted, with temperature) vs. T values are averaged as more bases are read. The melting map file gives data for the very last block melted.
*MeltSim 1.0 for Windows can be directed to melt in blocks marked with an Asterisk (*) in the input file. It can also read any part of a sequence by giving the start and stop locations.
*Multiple input files can be melted sequentially by using the asterisk wildcard (*) in the file name. With the automatic print function, MeltSim 1.0 for Windows can be left to work on any number of files, printing graphs as it goes.
*An output file is produced of melting curve coordinates (d[theta]/dT as a function of T).
you can free download MeltSim 1.0 now.


Please be aware that Brothersoft do not supply any crack, patches, serial numbers or keygen for MeltSim,and please consult directly with program authors for any problem with MeltSim.