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DensityFit 1.0

Electron microscopy has become an important tool in structural biology.


Last Week downloads: 0
Total downloads: 95
  • Last Updated: Aug 18, 2011
  • License: Freeware Free
  • OS: Windows XP/2000/98
  • Requirements: No special requirements

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For DensityFit 1.0Publisher's description


DensityFit is a Photo & Image software developed by Konrad Hinsen. After our trial and test, the software is proved to be official, secure and free. Here is the official description for DensityFit:

Brothersoft Editor: Electron microscopy has become an important tool in structural biology. Many proteins that cannot be made to crystallize in a 3D crystal suitable for X-ray crystallography can nevertheless be studied by electron microscopy, either as single molecules or in the form of 2D crystals.

However, the resulting structures have a much lower resolution. With rare exceptions, the electron Density maps obtained by electron microscopy are not sufficient to identify the structure at Atomic resolution.

In some situations, an atomic-level structure of the same protein in another conformation is available. DensityFit combines this information with the low-resolution structure by deforming the known atomic structure to make it fit into the low-resolution electron density map. The flexibility of the protein is described by an elastic network model, whose low-energy normal modes define the allowed deformations. This procedure guarantees that the integrity of the protein is preserved during the deformation.

Compared to other Similar algorithms that have been published, the one implemented in DensityFit has the advantage of having been tested on real experimental data for a mid-size protein, Ca-ATPase. The Algorithm and its application to Ca-ATPase have been described in.
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